GERD During Pregnancy*

Heartburn is a frequent occurrence during pregnancy. It is thought to be due to mechanical as well as hormonal changes. Lifestyle modifications and over-the-counter antacids are safe. H₂-RA  group of medications should only be used under the advice of a physician who would weigh the benefits and risks; however, they are generally considered safe - Pregnancy Category B - except for nizatidine [Axid] that is Category C.  PPIs are Category C with the exception of  lansoprazole which is considered Category B (and according to its manufacturer "should be used during pregnancy only if clearly needed").

* The following table describes teratogenic risk-factors as defined 
    by the US Food and Drug Administration:
          Category                      Description of Risk                 
                A               Controlled studies show no risk
                B                No evidence of risk in humans
                C                Risk cannot be ruled out
                D                Positive human evidence of fetal risk
                X                Contraindicated in pregnancy